Relationship Between High-Density Lipoprotein Cholesterol and Colorectal Cancer—A Mendelian Randomization Study
Objective To elucidate the causal relationship between high-density lipoprotein cholesterol(HDL-C)and colorectal cancer(CRC)through Mendelian randomization.Methods Mendelian randomi-zation analysis was conducted using genetic instrumental variables selected from a genome-wide association study dataset.The main methods included inverse variance weighted,MR-Egger,weighted median,simple mode,and weighted mode method;among which,inverse variance weighted method served as the primary analytical approach.Sensitivity analyses were performed to verify the robustness of results.Results A total of 41 genetic instrumental variables associated with HDL-C were identified.Inverse variance weighted method(OR=0.84,95% CI:0.73-0.96,P=0.01)and weighted median method(OR=0.82,95% CI:0.67-0.99,P=0.04)indicated a negative correlation between genetically-determined HDL-C and CRC risk.Sensitivity analyses confirmed the absence of heterogeneity and horizontal pleiotropy(P>0.05).Conclusion A causal relationship exists between HDL-C and CRC risk,with rs1077834 as a potential key determinant in the influence of HDL-C on CRC risk.
万方数据
维普
