Progress of Research on Transformation of Chronic Pancreatitis to Cancer
The transformation from inflammation to cancer is a complex pathological process,in which the inflammatory state progresses to the formation of malignant tumors.Chronic pancreatitis(CP)is a progr-essively inflammatory and fibrosing disease,predominantly featuring acinar cell atrophy owing to the cellular damage and fibrosis of the pancreatic parenchyma.This review centers on elucidating how prolonged exposure to a chronic inflammatory environment prompts adaptive changes in acinar cells,which may ultimately lead to their conversion into cancerous cells.By delving into the pivotal role of acinar-to-ductal metaplasia,this article investigates the multi-stage pathway of CP progression into pancreatic cancer,as well as the underlying molecular regulatory networks.We aim to light on the profound mechanisms of CP's inflammation-driven carcinogenic transformation,and thus provide a scientific foundation for devising innovative preventive strategies and therapeutic interventions targeted at mitigating or halting this lethal conversion process.
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维普
