首页|肿瘤患者生育力保护策略的现状与展望

肿瘤患者生育力保护策略的现状与展望

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随着疾病谱的改变,肿瘤发病率越来越高且趋于年轻化,肿瘤患者长期生存率大幅度提高,其生育权益也越来越被关注.手术、放化疗、免疫及分子靶向治疗是临床常用抗肿瘤治疗手段,对患者生育能力有不同程度影响.目前常见的生育保护技术包括精子冷冻保存、胚胎和卵母细胞冷冻保存、卵巢组织冷冻保存、子宫移植、生殖辅助技术等.本文系统总结了不同抗肿瘤治疗手段对生育力的影响以及肿瘤患者生育保存现状与展望,以期帮助临床肿瘤医生与生殖医学医生更好的合作,提高肿瘤患者的生育力.
Current Status and Prospects of Fertility Preservation Strategies for Patients with Tumors
With the changing disease spectrum,the incidence of tumors is increasing and tends to occur among the youth.The long-term survival rate of patients with cancer has increased significantly,and attention to their reproductive rights is growing.Surgery,chemotherapy,radiotherapy,immunotherapy,and molecular targeted therapy are the conventional treatment methods for cancer,with each exerting different effects on the fertility of patients.Common fertility preservation techniques currently include sperm cryopreservation,embryo and oocyte cryopreservation,ovarian tissue cryopreservation,uterine transplantation,and assisted reproductive technology.This article systematically summarizes the influence of different antitumor treatments on fertility,as well as the current status and prospects of fertility preservation in patients with cancer.This study aims to improve cooperation between clinical oncologists and reproductive medicine doctors to enhance fertility preservation for patients with cancer.

Fertility protectionRadiotherapyChemotherapyTargeted therapyImmune checkpoint inhibitor

姚昌悦、龚虹云、高炜熙、刘华丽

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430060 武汉,武汉大学人民医院肿瘤中心

443002 宜昌,三峡大学基础医学院

430060 武汉,武汉大学人民医院药学部

生育力保护 放射治疗 化疗 靶向治疗 免疫检查点抑制剂

2024

肿瘤防治研究
湖北省卫生厅,中国抗癌协会,湖北省肿瘤医院

肿瘤防治研究

CSTPCD
影响因子:0.737
ISSN:1000-8578
年,卷(期):2024.51(12)