T淋巴细胞亚群水平在晚期肺腺癌治疗中的变化及其临床意义
Changes of T-lymphocyte subsets level in treatment of advanced lung adenocarcinoma and their clinical significances
李小雪 1王鑫 1姚舒洋 1支修益1
作者信息
- 1. 100053 北京,首都医科大学宣武医院胸外科 首都医科大学肺癌诊疗中心
- 折叠
摘要
目的 探讨T淋巴细胞亚群水平在晚期肺腺癌治疗中的变化及临床意义.方法 选取2015年10月至2016年5月在首都医科大学宣武医院接受治疗的晚期肺腺癌患者96例为研究对象,其中转移63例,未转移23例.抽取外周血,采用流式细胞术检测CD3+、CD3+CD4+、CD3+CD8+、CD4+/CD8+、CD3-CD16+CD56+(NK)、CD8+CD28+、CD8+CD28-、调节性T细胞(Treg细胞)及CD3+γδ水平,并对检测结果进行统计学分析.结果 转移组患者CD3+γδ和Treg细胞水平高于未转移组(6.56±3.11比3.05±2.23;25.83±6.22比20.81±9.03),差异具有统计学意义(t=1.590,P=0.026;t=2.027,P=0.044);治疗有效患者CD45RA+水平(52.15±7.99)低于无效患者(70.26±17.33),差异有统计学意义(t=1.660,P=0.024).结论 检测晚期肺腺癌患者治疗中外周血T淋巴细胞亚群水平对预测治疗效果及预后具有一定的价值.
Abstract
Objective To investigate the changes and clinical significance of T-lymphocyte subsets in the treatment of advanced lung adenocarcinoma. Methods Ninety six patients with advanced lung adenocarcinoma who underwent treatment in Xuanwu Hospital Capital Medical University from October 2015 to May 2016 were selected as the subjects. There were 63 cases in the transferred group and 23 cases in the un-transferred group. The peripheral blood was taken, then flow cytometry was used to detect CD3+, CD3+CD4+, CD3+CD8+, CD4+/CD8+, CD3-CD16+CD56+(NK), CD8+CD28+, CD8+CD28-, Treg cells, CD3+γδ, and the results were analyzed statistically. Results The levels of CD3+γδand Treg cells in the transferred group were significantly higher than those in the un-transferred group (6.56±3.11 vs. 3.05±2.23; 25.83±6.22 vs. 20.81±9.03) (t=1.590, P=0.026; t=2.027, P=0.044). The level of CD45RA+in the effective group (52.15 ±7.99) was significantly lower than that in the untreated group (70.26 ±17.33) (t= 1.660, P= 0.024). Conclusion The detection of peripheral blood T-lymphocyte subsets in treatment of patients with advanced lung adenocarcinoma has a certain value in predicting the therapeutic effect and prognosis.
关键词
肺肿瘤/腺癌/流式细胞术/T淋巴细胞亚群Key words
Lung neoplasms/Adenocarcinoma/Flow cytometry/T-lymphocyte subsets引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据