Progress of lysine-specific demethylase 1 and its inhibitors in triple-negative breast cancer
林训义 1苏杭 1霍佳兴 1张风华 1杨璐
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作者信息
1. 河北省人民医院腺体外科，石家庄 050051
折叠
摘要
赖氨酸特异性去甲基化酶1（LSD1）是首个被发现的组蛋白去甲基化酶。近年来在恶性肿瘤的发生及发展研究中成为热点话题，其表达与恶性肿瘤的不良预后密切相关。目前已有研究指出，LSD1与三阴性乳腺癌（TNBC）的增殖、侵袭和转移有较强相关性，然而，关于其中的具体机制尚未完全清楚。文章总结了LSD1与TNBC发生、发展可能存在的机制，并综述LSD1在TNBC临床研究应用上的最新进展，为TNBC患者的药物联合治疗提供参考。 Lysine-specific demethylase 1 (LSD1) is the firstly discovered histone demethylase. In recent years, LSD1 has become a hot topic in the study of the development and progression of malignancies, and its expression is closely related to the poor prognosis of malignancies. At present, some studies have showed that LSD1 is strongly related to the proliferation, invasion and metastasis of triple-negative breast cancer (TNBC). However, the specific mechanism is not fully understood. This article summarizes the possible mechanism of the development and progression in LSD1 and TNBC, and reviews the latest progress of LSD1 in the clinical research application of TNBC, so as to provide a reference for drug combination therapy in TNBC patients.
Abstract
Lysine-specific demethylase 1 (LSD1) is the firstly discovered histone demethylase. In recent years, LSD1 has become a hot topic in the study of the development and progression of malignancies, and its expression is closely related to the poor prognosis of malignancies. At present, some studies have showed that LSD1 is strongly related to the proliferation, invasion and metastasis of triple-negative breast cancer (TNBC). However, the specific mechanism is not fully understood. This article summarizes the possible mechanism of the development and progression in LSD1 and TNBC, and reviews the latest progress of LSD1 in the clinical research application of TNBC, so as to provide a reference for drug combination therapy in TNBC patients.
关键词
赖氨酸特异性去甲基化酶1/乳腺肿瘤/肿瘤辅助疗法/治疗结果
Key words
Lysine specific demethylase 1/Breast neoplasms/Neoadjuvant therapy/Treatment outcome
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