Progress of the pathogenesis in mantle cell lymphoma
李燕玲 1秦小琪 2马艳萍 2杨璐
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作者信息
1. 山西医科大学第二临床医学院，太原 030001
2. 山西医科大学第二医院血液内科，太原 030001
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摘要
套细胞淋巴瘤（MCL）是一种罕见的B细胞淋巴瘤，其发病率在逐年升高。MCL兼具惰性淋巴瘤和侵袭性淋巴瘤的共同特点，病情进展迅速且预后不佳。最新研究认为，MCL的发病机制是一个连续统一体，细胞周期失调、SOX11过表达、表观遗传畸变等多种因素在疾病的不同阶段发挥作用。文章主要从分子遗传学角度讨论MCL的发病机制和不同亚型的新发现，进一步分析MCL的临床多样性。同时，通过对MCL发病机制的认识，旨在为MCL未来的治疗提供潜在的治疗靶点。 Mantle cell lymphoma (MCL) is a rare B cell lymphoma, and its incidence rate is increasing year by year. MCL has the common characteristics of both inert lymphoma and aggressive lymphoma: rapid progress and poor prognosis. The latest research believes that the pathogenesis of MCL is a continuum, and many factors such as cell cycle disorder, SOX11 overexpression, epigenetic aberration play a role in different stages of the disease. This paper mainly reviews the pathogenesis of MCL and new findings of different subtypes from the perspective of molecular genetics,and further analyzes the clinical diversity of MCL. At the same time, the understanding of the pathogenesis of MCL aims to provide potential targets for future treatment of MCL.
Abstract
Mantle cell lymphoma (MCL) is a rare B cell lymphoma, and its incidence rate is increasing year by year. MCL has the common characteristics of both inert lymphoma and aggressive lymphoma: rapid progress and poor prognosis. The latest research believes that the pathogenesis of MCL is a continuum, and many factors such as cell cycle disorder, SOX11 overexpression, epigenetic aberration play a role in different stages of the disease. This paper mainly reviews the pathogenesis of MCL and new findings of different subtypes from the perspective of molecular genetics,and further analyzes the clinical diversity of MCL. At the same time, the understanding of the pathogenesis of MCL aims to provide potential targets for future treatment of MCL.
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