Progress of diagnosis and treatment of MET variant digestive tract cancer
陈晨 1陈智琴 1高勇 1权明 1王姝雅 陈磊
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作者信息
1. 同济大学附属东方医院肿瘤科，上海 200123
折叠
摘要
消化道肿瘤的发病率日益升高且呈年轻化的趋势。随着精准医学概念的提出，通过特异性阻断肿瘤细胞信号转导，杀伤肿瘤细胞的分子靶向治疗逐步成为消化道肿瘤治疗的热点。文章以MET变异型消化道肿瘤为切入点，概述相关临床特征及分子机制，并总结了消化道肿瘤MET靶向治疗的最新进展。 The incidence of digestive tract cancer is increasing and tends to be younger. With the proposed concept of precision medicine, molecular targeted therapy that kills tumor cells by specifically blocking signal transduction leads a new era of digestive tract cancer therapy. This review takes MET variant digestive tract cancer as the entry point, gives an overview of its clinical features and molecular mechanisms, and summarizes the progress of MET targeted therapy for digestive tract cancer.
Abstract
The incidence of digestive tract cancer is increasing and tends to be younger. With the proposed concept of precision medicine, molecular targeted therapy that kills tumor cells by specifically blocking signal transduction leads a new era of digestive tract cancer therapy. This review takes MET variant digestive tract cancer as the entry point, gives an overview of its clinical features and molecular mechanisms, and summarizes the progress of MET targeted therapy for digestive tract cancer.
关键词
消化道肿瘤/细胞间质上皮转换因子/靶向疗法
Key words
Digestive system neoplasms/Cellular-mesenchymal epithelial transition factor/Targeted therapy
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