前折叠蛋白5的生物学功能与作用机制及其在恶性肿瘤中的研究进展
Biological function and action mechanism of prefoldin 5 and its advancements in malignant tumors
朱孝仁 1刘媛媛 2姜鉴倬 2陈敏斌1
作者信息
- 1. 江苏大学附属昆山医院肿瘤科,昆山 215300
- 2. 江苏大学附属昆山医院临床实验研究中心,昆山 215300
- 折叠
摘要
前折叠蛋白(PFDN)是一种六聚体形式的分子伴侣复合物,是新生蛋白正确折叠所必需的蛋白.PFDN5(又称MM-1)为PFDN的1个亚基,在促进细胞迁移、诱导细胞衰老等方面起着关键作用.多项研究证实,PFDN5的缺失、突变与肿瘤的发生、发展以及患者预后密切相关.文章就近年来针对PFDN5的生物学基础研究及其抗癌前景进行综述,旨在为恶性肿瘤的治疗提供新的潜在靶点.
Abstract
Prefoldin(PFDN),a hexameric chaperone complex,is crucial for the correct folding of nascent proteins.PFDN5,a subunit of PFDN,also known as MM-1,plays an essential role in regulating cell migration and senescence.Emerging evidences suggest that PFDN-5 deletion or mutation significantly contributes to the initiation and progression of multiple cancers and the prognosis of patients.In this paper,recent researches on the biological underpinnings of PFDN-5 and its anti-cancer prospect are reviewed,aiming to provide a novel potential therapeutic target for the treatment of malignancies.
关键词
肿瘤/前折叠蛋白/生物学现象/原癌基因蛋白质c-myc/分子靶向治疗Key words
Neoplasms/Prefoldin/Biological phenomena/Proto-oncogene proteins c-myc/Molecular targeted therapy引用本文复制引用
基金项目
国家自然科学基金(82072712)
国家自然科学基金(82273055)
出版年
2024
NETL
NSTL
万方数据