乙型肝炎病毒相关肝内胆管细胞癌的研究进展
Progress of hepatitis B virus-associated intrahepatic cholangiocarcinoma
刘天府 1李光明 1张岭漪1
作者信息
- 1. 兰州大学第二医院肝病科,兰州 730030
- 折叠
摘要
肝内胆管细胞癌(ICC)发病率低,恶性程度高且预后差.在我国,乙型肝炎病毒(HBV)相关ICC是最常见的ICC亚型,且其发病率呈上升趋势.HBV相关ICC的发病机制和临床特征不同于其他类型,近年来靶向治疗的应用为患者带来了更显著的生存获益.文章就HBV相关ICC发生的主要机制、患者临床特征及治疗的最新研究进展进行综述.
Abstract
Intrahepatic cholangiocarcinoma(ICC)is characterized with low incidence,high malignancy and poor prognosis.In China,hepatitis B virus(HBV)-associated ICC is the most common subtype of ICC and its incidence rate is on the rise.The pathogenesis and clinical characteristics of HBV-associated ICC are different from other types of ICC.In recent years,the targeted therapy has brought significant survival benefits for patients.This article reviews the pathogenesis of HBV-associated ICC and the latest research progress of the clinical characteristics and treatments of patients.
关键词
肝炎病毒,乙型/肝内胆管癌/感染/治疗Key words
Hepatitis B virus/Intrahepatic cholangiocarcinoma/Infection/Treatment引用本文复制引用
基金项目
甘肃省教育科技创新项目(2022B-047)
兰州大学第二医院"萃英科技创新"计划(CY2021-QN-A18)
出版年
2024
NETL
NSTL
万方数据