首页|抗体药物偶联物治疗非小细胞肺癌的研究进展和展望

抗体药物偶联物治疗非小细胞肺癌的研究进展和展望

Research progress and prospect of antibody-drug conjugates in the treatment of non-small cell lung cancer

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抗体药物偶联物(ADC)代表一种新兴抗肿瘤治疗策略,融合了单克隆抗体的高度特异性和高细胞毒性药物的杀伤力.相对于传统化疗药物,ADC不仅能够精准识别肿瘤靶点,还能够实现药物快速传递到肿瘤细胞内,在降低全身毒副作用的同时提供更高的治疗效力.ADC已经在多种肿瘤类型中展现了出色的治疗效果,在非小细胞肺癌(NSCLC)中的应用也备受关注,本文就ADC在NSCLC治疗中的研究现状和前景进行综述.
Antibody-drug conjugates(ADCs)represent an emerging anticancer therapeutic strategy that combines the high specificity of monoclonal antibodies with the lethality of highly cytotoxic drugs to fully leverage the advantages of tar-geted therapies.Compared with traditional chemotherapy drugs,ADCs can not only accurately identify tumor targets,but al-so achieve rapid delivery of drugs into tumor cells,providing higher therapeutic efficacy while reducing systemic toxic side effects.ADCs have shown excellent therapeutic effect in a variety of cancer types,and its research and application in the treatment of non-small cell lung cancer has also attracted much attention.This paper reviews the research status and pros-pects of ADCs in the treatment of non-small cell lung cancer.

Antibody-drug conjugatesNon-small cell lung cancerHuman epidermal growth factor receptorTropho-blast cell surface antigen 2

李雨凝、苏佳琳、罗永忠、张乐蒙

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湖南省肿瘤医院 胸部内一科,湖南 长沙,410013

湖南科技大学 生命科学与健康学院,湖南 湘潭,411201

抗体药物偶联物 非小细胞肺癌 人表皮生长因子受体 滋养层细胞表面抗原2

湖南省科技厅自然科学基金

2023JJ60039

2024

肿瘤药学
湖南省肿瘤医院

肿瘤药学

CSTPCD
影响因子:1.124
ISSN:2095-1264
年,卷(期):2024.14(4)