With the progress of treatment,the survival time of patients with advanced breast cancer has been significant-ly extended,but the probability of central nervous system metastases in patients is also increased.Although local treatments such as surgery and radiation therapy are still the main means of brain metastases treatment,drug treatment of brain metas-tases has become the focus of research in recent years.In particular,anti-human epidermal growth factor receptor 2(HER2)drugs,such as small-molecule tyrosine kinase inhibitors,have shown good efficacy in the drug treatment of HER2-positive brain metastatic breast cancer.In addition,some studies have also shown that drugs acting on other targets,such as anti-an-giogenic drugs,PARP inhibitors,and immune checkpoint inhibitors,also have a certain effect on brain metastases.
Breast cancerBrain metastasisChemotherapyTargeted therapyImmunotherapy
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