儿童患者鲍曼不动杆菌临床分布及耐药性分析
Clinical distribution and drug resistance of acinetobacter baumannii in children
何周康 1赵昕1
作者信息
- 1. 湖南省儿童医院药剂科,长沙410007
- 折叠
摘要
目的 了解儿童患者鲍曼不动杆菌的临床分布特征及耐药现状,为临床合理选用抗菌药物提供依据.方法 收集本院2010年1月至12月临床分离的124株鲍曼不动杆菌,采用K-B法检测药物敏感性.结果 124株鲍曼不动杆菌中,79株来自痰标本(占63.71％),20株来自血液标本(占16.13％).病区来源以ICU病房最高(40.32％),其次为呼吸内科(21.77％).在检测的19种药物中,耐药率超过50％的达13种(68.42％),且71株鲍曼不动杆菌呈多重耐药,占57.26％.耐药率最高为哌拉西林(81.45％),耐药率最低为多黏菌素B(1.61％),其次为头孢哌酮-舒巴坦(15.32％).结论 临床分离鲍曼不动杆菌多来源于呼吸道标本,以ICU和呼吸内科为主,且多重耐药现象十分严重.临床应加强对鲍曼不动杆菌耐药性监测,合理选用抗菌药物.
Abstract
Objective To investigate the clinical distribution and drug resistance of acinetobacter baumannii in childrea Methods The K-B method was used to detect the drug sensitivity of 124 acinetobacter baumannii isolated from Jan to Dec in 2010. Results Among the 124 strains of acinetobacter baumannii, 79 (63. 71%) were isolated from sputum and 20 (16. 13%) from blood. Strains isolated from the Intensive Care Unit accounted for 40. 32%, followed by those from the Respiratory Department (21. 77%). Among the 19 antibiotics tested, 13 (68. 42%) had resistance rate higher than 50. 0%, and 71 (57. 26%) were multi-resistant stains. Resistant rate to piperacillin (81. 45%) was the highest Resistance rate to polymyxin B (1. 61%) was the lowest, followed by cefoperazone-sulbactam (15. 32%). Conclusion Most clinically isolated acinetobacter baumannii are from respiratory specimens. Strains are mainly isolated from the Intensive Care Unit, Neurosurgery Department and Respiratory Department, with serious multi-resistance. Monitor of drug resistance of acinetobacter baumannii should be strengthened, and antimicrobial drugs should be used more rationally.
关键词
鲍曼不动杆菌/临床分布/耐药性Key words
acinetobacter baumanii/clinical distribution/drug resistance引用本文复制引用
出版年
2011
NETL
NSTL
维普
万方数据