Objective To study the chemical constituents and their protein tyrosine phosphatase 1B (PTP1B)inhibition of Cyclocarya paliurus (Batal) Ijinskaja.Methods The chemical constituents were isolated with a combination of reverse-phased materials and normal-phased materials.The PTP 1B inhibitory activities of the isolated compounds were assayed in vitro.Results Totally 16 compounds were isolated.They were identified as kaempferol-3-O-β-D-glucuronide (1),kaempferol-3-O-α-L-rhamnopyranoside (2),kaempferol-3-O-β-D-glucopyranoside (3),quercetin-3-O-α-L-rahamnopyranoside (4),kaempferol (5),benzoic acid (6),gallic acid (7),sodium (+)-isolaricireinoe-2a-sulfate (8),kaempferol-3-O-α-D-galactopyranoside (9),di-(2-ethylexyl)-phthalate (10),hexahydrocurcumin (11),5S-5-hydroxyl-l-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-3-heptanone (12),(+)-syringarensinol (13),zhebeiresinol (14),lirioresinol-A (15) and nicotinamide (16).Conclusion Compounds 8-16 have been isolated from Cyclocarya paliurus for the first time.Compound 10 shows significant inhibition against PTP 1B in vitro,with an IC50 value of (4.89± 0.37) μmol · L-1.
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