Research progress in STAT3 signal pathway in neurodegenerative diseases
Signal transducer and activator of transcription 3(STAT3)is an important signal pathway in the body,and many in vitro and in vivo studies have shown that this pathway is closely related to neurodegenerative diseases.Neuroinflammation caused by the activation of STAT3 plays an important role in the occurrence and development of neurodegenerative diseases.In Alzheimer's disease and Parkinson's disease,many physiological and biochemical studies have shown that STAT3 pathway is activated in patients and has a potential relationship with many pathological features,but its specific role remains controversial.In other neurodegenerative diseases,such as vascular dementia,Huntington's disease,amyotrophic lateral sclerosis and multiple sclerosis,STAT3 has less pathophysiological effects,and most studies focus on pharmacodynamics,which need further confirmation.This article reviewed the role of STAT3 signaling pathway in neurodegenerative diseases,and the latest research progress in STAT3 drugs targeting,to provide potential new targets for such diseases.
signal transducer and activator of transcription 3neuroinflammationneurodegenerative disease
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