Effect of multi-oil fat emulsion injection on non-specific inflammation,liver and kidney function and nutritional status in cancer patients
Objective To determine the effect of multi-oil fat emulsion injection(SMOF)on the non-specific inflammation,liver and kidney function and nutritional status in cancer patients after the surgery.Methods Patients who received SMOF and medium and long chain fat emulsion injection(MCT/LCT)from January 1st 2020 to 31st May 2023 were classified into a SMOF(the test group,n=47)and a MCT/LCT group(the control group,n=79)according to the type of fat emulsion,and recorded changes in non-specific inflammation,liver and kidney function,and nutritional indicators in both groups.Results Repeated measurement of analysis of variance(ANOVA)showed that in the non-age-limited cancer group,the time effect and intergroup effect differences in C-reactive protein(CRP),white blood cell count(WBC),total bilirubin(TBIL)and total protein(TP)of patients in both groups were significant(P＜0.05).The time effect difference in ALB was significant(P＜0.05).The CRP level of the test group was lower than that of the control group 7 days after the treatment,the WBC level 3 days and 7 days after the treatment was lower than that of the control group,the increase in TBIL was less than in the control group,and the TP level was higher than that of the control group(P＜0.05).The difference in other indicators was not significant.In the elderly cancer group,the time effect and intergroup differences in CRP,WBC,TBIL and TP of both groups of patients were significant(P＜0.05),and the time effect difference in ALB was significant(P＜0.05).The CRP and WBC levels of the experimental group were lower than those of the control group 3 days and 7 days after the treatment,and the TP levels was significantly higher than that of the control group.The increase in TBIL 3 days after the treatment in the experimental group was less than that of the control group(P＜0.05),and the differences in other indicators were not significant.Conclusion Compared with MCT/LCT,SMOF used for cancer patients after the surgery,including in elderly cancer patients,can reduce the inflammatory responses,protect patients'liver function and improve patients'nutritional status safely.
multi-oil fat emulsion injectioncancernon-specific inflammationliver and kidney functionnutritional status
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