Effect of different nutritional status on oxaliplatin-induced peripheral neurotoxicity(OIPN)in colorectal cancer patients
Objective To determine the effect of nutritional status on oxaliplatin-induced peripheral neurotoxicity(OIPN)in patients with colorectal cancer.Methods Totally 219 patients with colorectal cancer patients admitted to the Affiliated Hospital of Jiangnan University in Wuxi from July 2022 to May 2023 were selected.Patient data were collected,and the influencing factors were analyzed by SPSS 26.0.Results Peripheral neurotoxicity occurred in 144 of the 219 patients(the OIPN group),and the 75 patients did not have peripheral neurotoxicity(the non-OIPN group).Spearman analysis showed that comorbidity,NRS2002,albumin,and hemoglobin were significant(P＜0.05).Logistic regression analysis showed that albumin and comorbidity were the independent risk factors for the occurrence of OIPN in colorectal cancer patients,on the basis of which the Nomogram prediction model was constructed to offer new ideas for clinical assessment and prediction of OIPN.Conclusion Low albumin level and occurrence of comorbidities are independent risk factors for OIPN in colorectal cancer patients treated with oxaliplatin.The albumin level is closely related to the nutritional status of patients.This prediction model has good clinical application value for predicting the occurrence of OIPN in patients with colorectal cancer.
oxaliplatinoxaliplatin-induced peripheral neurotoxicityNRS2002nutritional status
万方数据
维普
