In vivo pharmacokinetics of evodiamine in rats after intravenous injection of evodiamine-glycyrrhizic acid micelles
Objective To establish an HPLC method to determine evodiamine in rat plasma and to study the intravenous pharmacokinetics of evodiamine-glycyrrhizic acid micelles in rats.Methods The rats were administerted evodiamine-glycyrrhizic acid micelles and evodiamine solution,respectively.The content of evodiamine in the rat plasma was determined by HPLC,and the pharmacokinetic parameters were analyzed by DAS 2.0 software.Results The Cmax of evodiamine-glycyrrhizic acid micelles and evodiamine solution was(1.61±0.19)and(0.92±0.11)μg·mL-1;AUC0～t was(4.76±1.41)and(2.07±0.22)mg·L-1·h;CL was(0.67±0.21)and(1.38±0.14)L·h-1·kg-1,respectively.The Cmax and AUC0～t were 1.75 and 2.30 times higher than those of evodiamine solution,while CL was 0.48 times higher than that of evodiamine solution.The difference in Cmax,AUC0～t and CL was significant(P＜0.05).Conclusion The conversion of evodiamine into micelles with glycyrrhizic acid may prolong the duration and metabolic processes of evodiamine in vivo.
万方数据
维普
