Medication rules of oral Chinese patent medicine for chronic cerebral circulation insufficiency
Objective To analyze the medication characteristics and composition rules of oral Chinese patent medicines for chronic cerebral circulation insufficiency,and to provide reference for clinical treatment and new drug development.Methods By searching CNKI,Wanfang,VIP,PubMed database and other Chinese and English databases,related literatures of Chinese patent medicines were screened.We established a database and collected useful information:dosage form,frequency of use,certificate type,frequency of use of single flavor Chinese medicine,taste attribution,and high-frequency drug pairs.SPSS Modeler software was used to associate the rules with traditional Chinese medicines.Results Totally 481 articles were collected,involving 86 Chinese patent medicines.The dosage form of Chinese patent medicines was mainly capsules.Yangxue Qingnao granules were most frequently used for multiple types of chronic cerebral circulation insufficiency.Single-flavor traditional Chinese medicines used frequently included Ligusticum chuanxiong,Salvia miltiorrhiza,Angelica sinensis,Astragalus membranaceus,Achyranthes bidentata,Glycyrrhiza uralensis,and Gastrodia elata,etc.,with medicinal taste mainly being warm medicine and bitter taste.The meridian covered mainly the liver,the heart and the spleen to activate the blood and remove the stasis and replenish the blood.Drugs with high-frequency included Ligusticum chuanxiong-Angelica sinensis,Ligusticum chuanxiong-Salvia miltiorrhiza,Ligusticum chuanxiong-Carthamus tinctorius and Ligusticum chuanxiong-Astragalus membranaceus,and their effects were mainly to replenish and activate blood,activate the blood and circulation,dispel the stasis,and invigorate qi.The rules association that the core components were Astragalus membranaceus,Ligusticum chuanxiong,Angelica sinensis,Carthamus tinctorius and Salvia miltiorrhiza.Conclusion There are multiple types of chronic cerebral circulation insufficiency.Ligusticum chuanxiong is mostly commonly used.Qiinvigorating and blood circulation activation are the basic mechanism,and Astragalus membranaceus,Ligusticum chuanxiong,Angelica sinensis,Carthamus tinctorius and Salvia miltiorrhiza consists of the core prescriptions.
Chinese patent medicinechronic cerebral circulation insufficiencymedication rule
万方数据
维普
