Advances in the mechanism of antitumor activity of artemisinin and its derivatives
In addition to their well-known antimalarial activity,artemisinin and its derivatives exhibit broad-spectrum antitumor activity.Artemisinin derivatives exert their antitumor effects through various mechanisms,including the induction of reactive oxygen species,cell cycle arrest in tumor cells,induction of apoptosis,inhibition of tumor angiogenesis,suppression of tumor cell invasion and metastasis,reversal of tumor drug resistance,and modulation of tumor immunity.This article summarized the latest research progress in the mechanism underlying the antitumor activity of artemisinin derivatives.
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