Impact of miRNAs on the development of esophageal cancer and intervention role of traditional Chinese medicine
Esophageal cancer is a common upper gastrointestinal malignant tumor.The total number of cases and deaths of esophageal cancer accounts for half of the world,greatly increasing the burden of cancer prevention and medical insurance in China.The early onset of esophageal cancer is insidious and hard to detect,resulting in most patients being in the middle and advanced stages at the time of diagnosis,and dalayed the treatment and unsatisfactory prognosis.As novel biomarkers,microRNAs(miRNAs)play an important role in tumor diagnosis,disease monitoring,and prognosis assessment.Recent studies have shown that miRNAs play the dual roles of tumor suppressor genes and anti-cancer genes in the formation of esophageal cancer microenvironment,radiotherapy and chemotherapy resistance,cancer cell proliferation,apoptosis,invasion,and autophagy,etc.,and are also potential intervention targets for esophageal cancer.However,the mechanism of miRNAs in the progression of esophageal cancer remains unclear,which limits their application as tumor markers in clinical diagnosis,treatment and prognosis of esophageal cancer.This paper systematically reviewed the dual regulatory mechanism of miRNAs in the occurrence and development of esophageal cancer and intervention with traditional Chinese medicine.
esophageal cancermiRNAsregulatory mechanismtumor celltraditional Chinese medicine
万方数据
维普
