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蒙药三子散多指标成分的含量测定

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目的 基于多指标成分含量测定结合灰色关联度分析(GRA)和逼近理想解排序法(TOPSIS)对蒙药三子散进行整体质量评价.方法 采用高效液相色谱(HPLC)法测定 15批三子散样品中诃子次酸、没食子酸、石榴皮鞣素、安石榴苷、jasminoside B、咖啡酸、柯里拉京、京尼平苷、诃子鞣酸、1,2,3,4,6-O-没食子酰葡萄糖、诃子林鞣酸、鞣花酸的含量,并对12种活性成分含量建立GRA和TOPSIS质量评价模型.结果 12种指标成分在各自质量浓度范围内与峰面积呈良好的线性关系,r均不小于 0.9995,平均回收率为 96.72%~104.07%,RSD为 1.4%~2.6%.GRA和TOPSIS分析结果基本一致,根据TOPSIS分析所得Ci值和GRA分析所得ri值可知,样品S1、S3、S4、S6、S10、S12、S14、S15 排名前 8.结论 GRA-TOPSIS法排除了人为因素的干扰,提高了多指标决策分析的科学性与准确性,精确地反映了各评价方案之间的差距,可对三子散进行整体质量评价及优质资源筛选.
Determination of multi-index components in Mongolian medicine Sanzi powder
Objective To conduct an overall quality evaluation of Mongolian medicine Sanzi powder based on multi-index component content determination combined with grey relational analysis(GRA)for order preference by similarity to ideal solution(TOPSIS)method.Methods The contents of chebulic acid,gallic acid,punicalin,punicalagin,jasminoside B,caffeic acid,corilagin,geniposide,chebulagic acid,1,2,3,4,6-O-pentagalloylglucose,chebulinic acid and ellagic acid were determined by HPLC,and the overall quality evaluation model was established by GRA combined with TOPSIS.Results Totally 12 indicator components showed a good linearity within their respective mass concentration ranges,with correlation coefficients r no less than 0.9995.The average recovery was 96.72%~104.07%,and the RSD was 1.4%~2.6%.The results of GRA and TOPSIS analysis were basically the same.According to the values from TOPSIS and GRA analysis,the sample S1,S3,S4,S6,S10,S12,S14,and S15 ranked the top 8 of all samples.Conclusion GRA-TOPSIS method eliminates the interference of human factors and transforms the mult-dimensional problem into one-dimension one,improves the science and accuracy of multi-index decision analysis,accurately reflects the gap between evaluation schemes,and the evaluates overall quality and screens high-quality resources of Sanzi powder.

Sanzi powdercontent determinationquality controlgrey relational analysistechnique for order preference by similarity to ideal solution

许佳绮、刘妍妍、白云霞、刘宏、夏慧敏、张慧文、王焕芸

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内蒙古医科大学药学院,呼和浩特 010110

濮阳市安阳地区医院药学部,河南 安阳 455000

内蒙古科技大学包头医学院,内蒙古 包头 014010

三子散 含量测定 质量控制 灰色关联度分析 逼近理想解排序法

内蒙古自治区自然科学基金项目内蒙古医科大学科技百万工程联合项目内蒙古自治区关键技术攻关计划项目

2022MS08023YKD2020KJBWLH0542021GG0176

2024

中南药学
湖南省药学会

中南药学

CSTPCD
影响因子:0.736
ISSN:1672-2981
年,卷(期):2024.22(2)
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