Objective To determine the clinical characteristics of thrombocytosis caused by low molecular weight heparin.Methods We searched both Chinese and English databases(as of May 2023),collected case reports of low molecular weight heparin-induced thrombocytosis,collected patient-related information,and descripbed the statistics.Results Totally 11 case reports of low molecular weight heparin-induced thrombocytosis were retrieved,involving 13 patients,with a median age of 57 years(0.1,67).Low molecular weight heparin was mainly used to treat or prevent venous thromboembolism.Seven patients had other diseases at the same time,and six patients described the combination use of other drugs.The median time of the occurrence of thrombocytosis was 8 d(3,28).There were no clinical manifestations in all patients.The median platelet count was 836×109·L-1(596×109·L-1,1234×109·L-1).After the low molecular weight heparin was discontinued in 13 patients,the platelets recovered to normal levels,and the median time to return to the normal range was 8 days(2,34).Conclusion Thrombocythemia caused by low molecular weight heparin may occur between 3 to 28 days,manifested as an increase in platelets.After discontinuing the low molecular weight heparin,the platelets return to normal levels.
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