金/多壁碳纳米管修饰玻碳电极检测盐酸曲美他嗪
Determination of trimetazidine hydrochloride by Au/MWCNTs modified glassy carbon electrode
崔紫瑞 1李帅晴 1许晴 1李聪瑞 1赵硕1
作者信息
- 1. 华北理工大学化学工程学院,河北省环境光电催化材料重点实验室,河北 唐山 063210
- 折叠
摘要
目的 建立金/多壁碳纳米管(Au/MWCNTs)修饰的玻碳电极检测人尿液中盐酸曲美他嗪(TMZ)的电化学方法.方法 采用微流控法,以氯金酸为金源、抗坏血酸为还原剂合成了金微粒(AuMPs,110nm),并用Au/MWCNTs修饰玻碳电极检测TMZ,对pH和扫描速度等条件进行优化.结果 优化条件为pH 3.0,扫描速度135mV·s-1.TMZ在8×10-8～8×10-6 mol·L-1与响应信号电流值呈现良好的线性关系,检测限为8×10-9mol·L-1.并实现了人体尿液中的盐酸曲美他嗪的加标检测.结论 本方法可用于兴奋剂的检测.
Abstract
Objective To establish an electrochemical method to detect trimetazidine hydrochloride(TMZ)in human urine with a gold/multi-walled carbon nanotubes(Au/MWCNTs)modified glassy carbon electrode.Methods Gold nanoparticles(AuMPs,110 nm)were synthesized with chloroauric acid as the gold source and ascorbic acid as the reducing agent via microfluidic method.The Au/MWCNTs modified glassy carbon electrode was used to detect TMZ,and the pH and scan rate were optimized.Results The optimized conditions were pH 3.0 and a scan rate of 135 mV·s-1.The concentration of TMZ at 8 X 10-8 to 8×10-6 mol·L-1 showed a good linearity with the response current value,with the detection limit of 8×10-9 mol·L-The method was successfully applied to the spiked detection of TMZ in human urine.Conclusion This method can be used in the detection of stimulants.
关键词
微流控/金微粒/修饰电极/盐酸曲美他嗪Key words
microfluidic/gold nanoparticles(AuMPs)/modified electrode/trimetazidine hydrochloride引用本文复制引用
基金项目
博士启动金项目(28423299)
大创基金(XX20233523)
出版年
2024
NETL
NSTL
万方数据