Determination of trimetazidine hydrochloride by Au/MWCNTs modified glassy carbon electrode
Objective To establish an electrochemical method to detect trimetazidine hydrochloride(TMZ)in human urine with a gold/multi-walled carbon nanotubes(Au/MWCNTs)modified glassy carbon electrode.Methods Gold nanoparticles(AuMPs,110 nm)were synthesized with chloroauric acid as the gold source and ascorbic acid as the reducing agent via microfluidic method.The Au/MWCNTs modified glassy carbon electrode was used to detect TMZ,and the pH and scan rate were optimized.Results The optimized conditions were pH 3.0 and a scan rate of 135 mV·s-1.The concentration of TMZ at 8 X 10-8 to 8×10-6 mol·L-1 showed a good linearity with the response current value,with the detection limit of 8×10-9 mol·L-The method was successfully applied to the spiked detection of TMZ in human urine.Conclusion This method can be used in the detection of stimulants.
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