Research progress in cocrystal improvement of druggable properties of flavonoids
Flavonoids are natural organic compounds with many types and quantities.They have attracted much attention due to their extensive pharmacological activities,and have become a hot spot in the development and research of natural drugs at home and abroad.However,flavonoids also have problems such as poor water solubility,low bioavailability and instability in vivo,which limit their clinical application.Because flavonoids usually lack ionizable groups,cocrystal strategy is often an effective way to improve the solubility and bioavailability of these compounds.The effects of flavonoids cocrystal successfully prepared in recent years on the solubility,dissolution rate,permeability and bioavailability of raw materials were reviewed and its mechanism was briefly introduced to provide reference for further development and in-depth research of flavonoids cocrystal products.
flavonoidcocrystaldruggable propertymechanism of change
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