中药抗电离辐射药理作用及机制研究进展
Research progress in pharmacological action and mechanism of Chinese medicine against ionizing radiation
王帅 1李航 1王闯闯 1赵孟楠 1李祎亮 2侯文彬 2周福军3
作者信息
- 1. 天津中医药大学,天津 301617
- 2. 北京协和医学院&中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津 300192
- 3. 天津药物研究院,天津 300462
- 折叠
摘要
中药具有高效、低毒、多靶点、特异性强等特点,其在辐射防护方面有着独特的优点.基于辐射对机体中免疫系统、造血系统和生殖系统的相关细胞及其通路损伤,以及DNA损伤和抗氧化应激,本文论述了近十年来中药及其复方抗辐射药理作用及机制的研究进展,并提出现有研究存在的问题,以期为后续新型辐射防护剂的中药产品开发提供参考.
Abstract
Traditional Chinese medicine is characterized by its high efficiency,low toxicity,multiple targets and strong specificity,as well as its unique advantages in radiation protection.Based on radiation damage to cells and their pathways in the immune system,hematopoietic system and reproductive system,as well as DNA damage and antioxidant stress,this paper reviewed recent research progress in the pharmacological action and mechanism of anti-radiation in traditional Chinese medicine.Chinese medicine compounds over the past decades are reviewed and the existing problems are presented to provide a reference for the development of new radiation protection agents in Chinese medicine products.
关键词
中药/抗辐射/药理作用/作用机制/研究进展Key words
traditional Chinese medicine/anti-radiation/pharmacological action/mechanism of action/research progress引用本文复制引用
基金项目
国家自然科学基金(82104012)
国家自然科学基金(82202950)
中国医科院医学与健康科技创新工程重大协同创新项目(2021-I2M-1-042)
出版年
2024
NETL
NSTL
万方数据