Clinical effect of tuberculosis pills combined with anti-tuberculosis chemotherapy drugs on children with pulmonary tuberculosis
Objective To determine the clinical efficacy and safety of tuberculosis pills combined with standard chemotherapy treatment in children with newly diagnosed pathogen positive pulmonary tuberculosis.Methods Children newly diagnosed pathogen positive pulmonary tuberculosis from June 2018 to June 2022 were retrospectively analyzed,and divided into a tuberculosis pill group and a control group based on whether they had used tuberculosis pills.The tuberculosis pill group was given tuberculosis pills plus standard chemotherapy treatment including HRZ(E),while the control group was only given HRZ(E).Results Totally 61 children were included in the tuberculosis pills group and 101 children in the control group.There was no significant difference in the baseline information between the two groups before the treatment.After two months of treatment,the sputum negative conversion rate,and focus absorption effective rate in the tuberculosis pill group were much higher than those in the control group(P＜0.05).The hemoglobin and serum pre-albumin in the tuberculosis pill group improved more significantly than those in the control group,but the blood uric acid elevation in the tuberculosis pill group was lower than that in the control group(P＜0.05).In terms of safety,the overall incidence of adverse drug reactions in the tuberculosis pills group showed no significant different in the two groups,but the incidence of liver dysfunction in the tuberculosis pill group was much lower than that in the control group(P＜0.05).Conclusion Besides standard chemotherapy treatment,tuberculosis pills help increase the rate of negative conversion of sputum bacteria,promote lung lesion absorption,improve anemia and malnutrition,and reduce the incidence of anti-tuberculosis drug-induced liver injury in children with newly diagnosed pathogen positive pulmonary tuberculosis.
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万方数据
