Stability of the active component echinacetin in Erzhi pills based on a degradation kinetics model
Objective To establish a degradation kinetics model of phenylethanoid glycosides-echinacoside monomer and its degradation in Erzhi pills under various conditions,and to determine the effect of preparation on the active components.Methods Ultra-high performance liquid chromatography(UPLC)was used to determine the content of echinacoside(monomers,Erzhi pills)under different environmental interferences,and the degradation kinetics model was established.Results Echinacoside(monomers,Erzhi pills)was degraded under various conditions,and the degradation rule under different environmental disturbances was classified as(pseudo)first-order reaction.The degradation rate of echinacoside in the form of preparation was slower than that of echinacoside monomers.Conclusion Echinacoside should be stored in dry and dark environment,with low temperature,and try to avoid contacting with alkaline solution and iron.Erzhi pills can delay the degradation rate of echinacoside monomers under various conditions.
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