基于降解动力学模型的二至丸的活性成分松果菊苷稳定性研究
Stability of the active component echinacetin in Erzhi pills based on a degradation kinetics model
郝冰玉 1陈微 2陈园 2王冬萍 1任晓亮 2王萌 1刘艺2
作者信息
- 1. 天津中医药大学组分中药国家重点实验室,天津 301617
- 2. 天津中医药大学中药学院,天津 301617
- 折叠
摘要
目的 建立苯乙醇苷类成分-松果菊苷单体及其在二至丸中的降解动力学模型,研究制剂对活性成分的影响.方法 使用超高效液相色谱法(UPLC)测定不同环境干扰下的松果菊苷(单体、二至丸)含量变化,并建立其降解动力学模型.结果 松果菊苷(单体、二至丸)在多种条件下可发生降解,在不同环境干扰下降解规律可归为(伪)一级反应;制剂形式下的松果菊苷降解速度较松果菊苷单体慢.结论 松果菊苷更适合储存在干燥、低温、避光条件下,尽量避免与碱性溶液、铁器接触;二至丸制剂能够延缓松果菊苷单体在多种条件下的降解.
Abstract
Objective To establish a degradation kinetics model of phenylethanoid glycosides-echinacoside monomer and its degradation in Erzhi pills under various conditions,and to determine the effect of preparation on the active components.Methods Ultra-high performance liquid chromatography(UPLC)was used to determine the content of echinacoside(monomers,Erzhi pills)under different environmental interferences,and the degradation kinetics model was established.Results Echinacoside(monomers,Erzhi pills)was degraded under various conditions,and the degradation rule under different environmental disturbances was classified as(pseudo)first-order reaction.The degradation rate of echinacoside in the form of preparation was slower than that of echinacoside monomers.Conclusion Echinacoside should be stored in dry and dark environment,with low temperature,and try to avoid contacting with alkaline solution and iron.Erzhi pills can delay the degradation rate of echinacoside monomers under various conditions.
关键词
松果菊苷/二至丸/降解动力学/稳定性/UPLCKey words
echinacoside/Erzhi pill/degradation kinetics/stability/UPLC引用本文复制引用
出版年
2024
NETL
NSTL
万方数据