Preparation and in vitro transdermal research of agomelatine ionic liquid patch
Objective To prepare transdermal patch of agomelatine ionic liquids and evaluate its quality.Methods The excipients used in the prescription were selected by drug precipitation,in vitro release and in vitro permeation.Agomelatine-docusate ionic liquid was prepared by ion-exchange reaction and the physicochemical properties of this ionic liquid were systematically characterized by FT-IR and NMR.The transdermal patches were prepared by solvent evaporation,and the content uniformity,in vitro release and in vitro permeation of ionic liquid patches were evaluated.Results The prepared agomelatine ionic liquid patch had smooth and transparent surface,the weight area ratio was 167 g·m 2,and the drug content per unit area was 2.5 mg·cm-2.The content uniformity met pharmacopoeia standards.The in vitro release rate was(478.31±0.87)μg/(cm2·h1/2).The permeation rate in vitro was(24.38±3.93)μg/(cm2·h).The cumulative permeation amount was(545.86±93.08)μg·cm-2 at 24 h,and the permeability was(21.78±3.85)％.Conclusion The agomelatine ionic liquid significantly improves the transdermal effect of the patch by increasing drug-carrying capacity of the patch,enabling transdermal patches to be a novel delivery formulation for agomelatine.
agomelatineionic liquidtransdermal patchin vitro permeation test
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