Advance in regulation of microglial cells on tau proteins in Alzheimer's disease
Microglia cells are important cells that constitute the innate immune system of the brain,which help maintain the homeostasis of the central nervous system and protect the neurons from pathogenic damage.In recent years,as the close association between microtubule-associated unit(tau)and the pathogenesis of Alzheimer's disease(AD)has been revealed so has the regulatory role of microglial cells on tau proteins.The triggering receptor on myeloid cells 2(TREM2)has been identified as a risk factor for AD,playing an important regulatory role in microglial function and tau proteins pathology.This article summarized the regulation of microglia on tau proteins in AD pathology,and explored the impact of TREM2 on both,in the hope of providing insights into the mechanism and treatment of AD.
microglial celltau proteinAlzheimer's diseasetriggering receptor expressed on myeloid cells 2
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