Advances in the pharmacological study of terazosin
Terazosin(TZ)is a novel antihypertensive drug.As an analogue of prazosin,terazosin can selectively block the postsynaptic α1-adrenal receptor,relax the vascular smooth muscle,and control the blood pressure.Compared with prazosin,terazosin has a more moderate antihypertensive effect with a long action time and a good linear dose-effect relationship.Many studies in Europe and the United States have shown that it is a long-acting new antihypertensive drug,superior to prazosin.At the same time,terazosin can relax the muscles of the prostate and bladder neck,and facilitate urinationsuiable for benign prostate diseases.In neurodegenerative diseases(Parkinson's disease,amyotrophic lateral sclerosis,Alzheimer's disease,multisystem atrophy,etc.),terazosin binds and activates PGK1,protects the neurons by enhancing PGK1 activity and promoting glycolysis.Recent studies have linked terazosin to the treatment of some gastrointestinal disorders,post-traumatic stress disorder,hyperhidrosis,and stroke.This paper reviewed the basic situation,pharmacokinetics,clinical application and pharmacological action of terazosin to provide reference for its future research.
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