Impact of centralized drug volume-based procurement policy on the prescribing behaviors and bacterial resistance of quinolone injection
Objective To determine the effect of centralized drug volume-based procurement policy on the use of quinolone injection and changes in bacterial resistance.Methods Data of quinolone injection use in Nanjing Drum Tower Hospital from January 2017 to October 2019 and from January 2020 to October 2022 were collected.The impact of policy was analyzed with interruption time series model.The opinions of medical staff on centralized drug procurement and the reasons of corresponding behaviors were analyzed based on questionnaires.The correlation analysis was conducted with bacterial resistance rate and the detected quantity in corresponding time period.Results After the implementation of the policy for the third time,the use of moxifloxacin decreased.After the implementation of the policy for the fifth time,the use of moxifloxacin and ciprofloxacin began to increase,and there was a difference between the changes in the control group and the impact of the policy(P＜0.05).In contrast,levofloxacin use continued to decline.The questionnaire showed that quinolones were preferred as alternative drugs,which was consistent with the rise in quinolones use after the fifth implementation.The resistance rate of quinolone drugs did not obviously increase due to policy influence,without clear correlation with the usage of quinolone drugs.Conclusion The usage of quinolone drugs decreases after the third implementation of the policy of centralized procurement and does not show abnormal growth after the fifth implementation.The resistance rates of relevant pathogens are not highly correlated with the drug usage.Long-term monitor of the impact of policies on the resistance rate is necessary.
centralized drug volume-based procurement policyquinoloneinterrupted time-series analysisresistance rate
NETL
NSTL
万方数据
