摘要
二氢杨梅素是一种主要存在于葡萄科蛇葡萄属植物中的黄酮类化合物,具有抗氧化、抗炎、抗肿瘤、抗病原微生物、抗衰老、解酒保肝、防治心脑血管及代谢性疾病等多种药理学作用.近年来,二氢杨梅素对肝脏疾病包括急性肝损伤、酒精性肝病、代谢功能障碍相关的脂肪变性肝病、病毒性肝炎、肝纤维化以及肝癌等的保护作用得到了大量的研究和报道.本文对二氢杨梅素对肝脏疾病的保护作用及机制进行综述,以期为二氢杨梅素相关药物研发及临床防治肝脏疾病提供参考.
Abstract
Dihydromyricetin is a flavonoid compound mainly present in plants of the Ampelopsis genus in grape family.It has various pharmacological effects such as antioxidation,anti-inflammation,anti-tumor,anti-microbe,anti-aging,anti-alcohol and liver protection,prevention and treatment of cardiovascular,cerebrovascular,and metabolic diseases.Recently,the protective effects of dihydromyricetin on liver diseases including acute liver injury,alcoholic liver disease,metabolic dysfunction-associated steatotic liver disease,viral hepatitis,liver fibrosis,and liver cancer have been extensively studied.This article reviewed the protective effect and mechanism of dihydromyricetin on liver diseases,to provide reference for the development of dihydromyricetin-related drugs and products,as well as the clinical prevention and treatment of liver diseases.
基金项目
陕西省自然科学基础研究计划(2024JC-ZDXM-50)
陕西省重点研发计划(2018SF-014)
NETL
NSTL
万方数据