Research progress in the role of peroxisome proliferator-activated receptor-γ and its agonists in rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease characterized by polyarticular synovitis,whose pathogenesis has not been fully elucidated.Peroxisome proliferator-activated receptor-γ(PPARγ)is a member of the ligand-activated nuclear transcription factor superfamily,which plays an important role in immune regulation,inflammation control and bone stability.It is important to determine the role of PPARγ in rheumatoid arthritis.This article reviewed the role of PPARγ in rheumatoid arthritis,and the development of therapeutic drugs based on the target of PPARγ,so as to provide reference for the development of new drugs for rheumatoid arthritis.
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