Objective To determine the protective effect of Naoluoxintong(NLXT)on lipid peroxidation injury and mitochondrial damage after ischemic stroke.Methods SPF male SD rats were used to establish the cerebral ischemic/reperfusion model by suture method.The neurological function was evaluated according to Zea Longa standards.The model animals with scores of 2～3 were randomly divided into a model group,and NLXT low,middle,and high dose groups.A sham operation group and a normal group were also established.The rats were treated with NLXT for 7 days,meanwhile,rats in the normal and the sham-operated groups were gavaged with saline.The effect of NLXT on living condition,body weight,neurological function score,brain histopathology,lipid peroxide(LPO)content,4-hydroxyenal(4-HNE)level,mitochondrial morphology and hypoxia inducible factor-1α expression were observed.Results Compared with the model group,NLXT improved the rat's quality of life,increased the body weight and their neurological function,reduced the accumulation of LPO,4-HNE and HIF-1α,and protected against the pathological damage of the brain tissue and the structure of mitochondria.Conclusion NLXT plays a neuroprotective role by inhibiting lipid peroxidation and protecting mitochondrial damage after ischemic stroke.
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