Pharmacokinetics of paeoniflorin in normal and intrahepatic cholestatic rats by LC-MS/MS
Objective To compare the pharmacokinetic process of paeoniflorin in normal rats and rats with 17α-ethinylestradiol-induced cholestatic liver injury.Methods The content of paeoniflorin in the rat plasma samples at different time points after the administration was detected by LC-MS/MS.The pharmacokinetic parameters of the two groups were analyzed by DAS 2.0 software.Results The pharmacokinetic behaviors of rats changed after the development of cholestatic liver injury as compared to those of normal rats.Specifically,t1/2Z,MRT0～∞,AUC and Vz/F of paeoniflorin were obviously increased,while CLz/F was greatly decreased.Conclusion Compared with the normal rats,the concentration of paeoniflorin is higher and the elimination rate slower in the cholestatic model rats.
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