Preparation and evaluation of tandospirone transdermal patches
Objective To prepare tandospirone transdermal patches and evaluate their quality.Methods Synthesized of choline-oleic acid ionic liquid was used as a combined osmotic promoter.The prescriptions were screened and optimized by a one-way test with appearance and cumulative transmittance as the evaluation indexes.Pharmacokinetic characteristics of the patches were determined by SD rat test.Results Tandospirone transdermal patches included:10%tandospirone,7.5%choline-oleic acid,7.5%isopropyl myristate,and 75%DURO-TAK 4098.The 24-hour cumulative permeation was(309.33±45.98)μg·cm-2,and the transdermal steady-state flux was(13.43±1.93)μg·cm-2·h-1.SD rats experiments showed that tandospirone transdermal patches held slow-release characteristics compared with tandospirone suspension,with T1/2 being extended to(6.37±4.46)h and MRT0～t increased by 17-folds.Conclusion Tandospirone transdermal patches show sustained release effects and become a new drug delivery formulation for tandospirone.
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