摘要
线粒体是动态的细胞器,对于真核细胞的能量产生和稳态维持至关重要.脂肪细胞通常被认为是终末分化的细胞,成熟脂肪细胞的功能紊乱是肥胖症的特点之一.在脂肪细胞中,线粒体调节脂肪细胞分化、脂质代谢、产热作用、葡萄糖利用和胰岛素敏感性.而脂肪细胞中线粒体功能障碍与肥胖等代谢性疾病高度相关.所以线粒体可能是治疗肥胖症的潜在重要靶点.本文深入探讨了脂肪细胞中线粒体的功能,并总结了以线粒体为靶点治疗肥胖的相关药物,为临床肥胖症的治疗提供新的方向和思路.
Abstract
Mitochondria,the dynamic powerhouses of the cell,play a critical role in energy production and maintaining cellular equilibrium in eukaryotic organisms.Adipocytes,commonly known as fat cells,are considered fully differentiated cells.Mature adipocyte dysfunction is a hallmark of obesity.Within these cells,mitochondria are pivotal in regulating such functions as fat cell differentiation,lipid management,thermogenic processes,glucose utilization,and insulin responsiveness.Additionally,mitochondrial impairments in the adipocytes are closely linked to metabolic disorders,notably obesity,underlining mitochondria's role as a promising target for obesity management.This review explored the critical role of mitochondria in adipocyte operations and highlighted emerging mitochondrial-targeted therapies for obesity,offering novel perspectives and strategies for the clinical management of obesity.
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