Research progress in hypoglycemic agents for nonalcoholic fatty liver disease complicated with type 2 diabetes mellitus
Nonalcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are both common.They often coexist or affect the occurrence and development of other diseases at the same time.Insulin resistance may be the key common pathogenesis.In recent years,the incidence rate of NAFLD has increased year by year.Current studies have shown that some hypoglycemic drugs can not only effectively manage blood glucose,but also improve liver steatosis,ballooning,liver fibrosis and inflammation indicators,which may be potential drugs for NAFLD.This article reviewed the effects of metformin,DPP-4 inhibitors,GLP-1 receptor agonists,SGLT-2 inhibitors,and PPAR agonists on NAFLD patients with T2DM,providing ideas for the treatment of NAFLD and reference for subsequent drug research.
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