Applicability of optimized triggers in monitoring adverse events in patients with cardiovascular diseases
Objective To verify the applicability of optimized triggers in monitoring adverse drug events(ADE)in patients with cardiovascular diseases.Methods Delphi method was used to collect experts'opinions to optimize the triggers.According to the inclusion/exclusion criteria,medical records of discharged patients from the Department of Cardiovascular Medicine of a TierⅢ Grade A hospital in 2022 were reviewed to evaluate the advantages of triggers in improving the detection rate of ADE.Results Among 240 cases,206 positive items and 169 patients were detected by the trigger,and 107 items and 74 patients were determined with ADE,with an overall positive predictive value(PPV)of 51.94%(107/206).The most severe ADE severity was grade E damage,accounting for 89.19%.Totally 9 systems-organs were involved,and the most damaged was the gastrointestinal system damage(55 cases),followed by metabolic and nutritional disorders(18 cases).The detection rate of active monitoring was 30.83%(74/240),and the independent reporting rate of the medical institution was 0.28%(6/2166)in the same period,with a significant difference(P＜0.05).Conclusion Compared with autonomous reporting system,optimized cardiovascular drug triggers are reasonably designed and effectively improve the detection rate of ADE.
global trigger toolDelphi methodadverse drug eventactive monitoringcardiovascular system drug
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