Meta-analysis of clinical efficacy and safety of generic and original insulin glargine for type 2 diabetes mellitus
Objective To evaluate the clinical efficacy and safety of original and generic insulin glargine for type 2 diabetes mellitus(T2DM).Methods Domestic and foreign literatures were systematically reviewed.Meta-analysis was used for the evaluation the efficiency and safety.Results Meta-analysis showed that there was no significant difference in reducing fasting blood glucose,glycosylated hemoglobin(HbA1c)level and HbA1c compliance rate(P＞0.05)between the generic and the original drug.There was no significant difference in the incidence of hypoglycemia and total adverse reactions between domestic and imported insulin glargine(P＞0.05).Conclusion There is no significant difference between insulin glargine generic and original drugs in the efficacy and safety.However,limited by the quality and quantity of the included literatures,large sample and multi-center RCT are needed to further confirm this conclusion.
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