Preparation and evaluation of esomeprazole drug resin complex coated microcapsules
Objective To prepare esomeprazole drug resin complex coated microcapsules(ESO-CM)with enteric-coating effect through ion exchange and fluidized bed coating.Methods ESO drug resin complex(ESO-DRC)was prepared with static drug loading using porous anion exchange resin as the carrier.The binding mechanism and in vitro release were determined.ESO-DRC was coated with fluidized bed coating to prepare ESO-CM,whose morphology and in vitro release was observed.Results The drug loading of ESO-DRC was 0.93 mg ESO/1 mg resin,with drug utilization rate at 92.30％.The combination of resin and ESO was achieved through ionic bonds.Under the in vitro release conditions of 900 mL 0.15 mol·L-1 NaCl solution,medium temperature of(37±0.5)℃,and rotation speed of 50 r·min-1,about 90％of ESO-DRC was released within 60 min.ESO-CM had uniform particle size and content,smooth surface,and significant enteric dissolution effect.Conclusion This study successfully develops a stable ESO-CM with enteric-coating effect.
esomeprazoleion exchange resinfluidized bed coatingcoated microcapsule
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