Optimization of drying process of Atirilali tablet
Objective To optimize the drying process of the liquid extract in the hospital preparation of Atirilali tablets.Methods Orthogonal experimental design was adopted.The drying method(electric vacuum drying,oven drying,and atmospheric water bath drying),drying time(12,24,and 36 h),and drying temperature(60,70,and 80 ℃)were evaluated.The comprehensive scores of isochlorogenic acid A,B,C content determined by HPLC were used as the evaluation index,the drying process of fluid extract was optimized.Results The orthogonal test showed that the drying method and conditions of the liquid extract of Atirilali tablets had little effect on the content of the ingredients.In the drying process of the electric vacuum at 70 ℃ for 24 hours had the best effect.The paste was non-viscous and fully pulverized.Conclusion The best drying process of the liquid extract of Atirilali tablets in the hospital include electric vacuum at 70 ℃ for 24 hours.This study provides a scientific basis for optimization of the preparation process of Atirilali tablets.
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