首页|G1-熵权法结合Box-Behnken响应面法优化银星养脑方醇提工艺

G1-熵权法结合Box-Behnken响应面法优化银星养脑方醇提工艺

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目的 优化银星养脑方醇提工艺.方法 基于单因素实验,以乙醇浓度、提取时间、提取溶剂倍数为影响因素,采用Box-Behnken响应面法,以阿魏酸、3,6'-二芥子酰基蔗糖、金松双黄酮、异银杏素的转移率和浸膏得率为评价指标,结合G1-熵权法计算综合评分,优选银星养脑方最佳醇提工艺.结果 建立了工艺评价函数模型,模型预测最佳提取工艺为6倍量60％的乙醇提取1.4 h,提取2次.结论 该提取方法稳定可行,可为银星养脑方的批量生产提供参考.
Optimization of alcohol extraction of Yinxing Yangnao formula by G1-entropy weight method combined with Box-Behnken response surface methodology
Objective To optimize the alcohol extraction of Yinxing Yangnao formula.Methods Based on the single factor experiments,ethanol concentration,extraction time and times of extraction solvent were used as the influence factors.Box-Behnken response surface methodology was used,and the transfer rates of ferulic acid,3,6'-disinapoyl sucrose,sciadopitysin,isoginkgetin and extract yield as evaluation indexes.Combined with G1-entropy weight method,the comprehensive score was calculated to optimize the alcohol extraction of Yinxing Yangnao formula.Results The model predicted that the optimal extraction process was extraction with 6 times of 60％ethanol for 1.4 h and 2 extractions.Conclusion The extraction method is stable and feasible,which can provide a theoretical basis for the mass production of Yinxing Yangnao formula.

Yinxing Yangnao formulaalcohol extraction processG1-entropy weight methodBox-Behnken response surface methodology

熊丹、蒋翠平、牛江进、严建业、王平杰、谢宗明、高明果、陶叶琴

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浏阳市中医医院,湖南 浏阳 410300

湖南中医药大学,长沙 410006

银星养脑方 醇提工艺:G1-熵权法 Box-Behnken响应面法

长沙市卫健委中医药科研重点项目湖南省自然科学基金项目长沙市自然科学基金项目湖南省临床医疗技术创新引导项目

A2023042024JJ9573kq22024972021SK51501

2024

10.7539/j.issn.1672-2981.2024.07.010

中南药学
湖南省药学会

中南药学

CSTPCD
影响因子：0.736
ISSN：1672-2981
年,卷(期)：2024.22(7)
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