G1-熵权法结合Box-Behnken响应面法优化银星养脑方醇提工艺
Optimization of alcohol extraction of Yinxing Yangnao formula by G1-entropy weight method combined with Box-Behnken response surface methodology
熊丹 1蒋翠平 1牛江进 1严建业 2王平杰 2谢宗明 1高明果 1陶叶琴1
作者信息
- 1. 浏阳市中医医院,湖南 浏阳 410300
- 2. 湖南中医药大学,长沙 410006
- 折叠
摘要
目的 优化银星养脑方醇提工艺.方法 基于单因素实验,以乙醇浓度、提取时间、提取溶剂倍数为影响因素,采用Box-Behnken响应面法,以阿魏酸、3,6'-二芥子酰基蔗糖、金松双黄酮、异银杏素的转移率和浸膏得率为评价指标,结合G1-熵权法计算综合评分,优选银星养脑方最佳醇提工艺.结果 建立了工艺评价函数模型,模型预测最佳提取工艺为6倍量60％的乙醇提取1.4 h,提取2次.结论 该提取方法稳定可行,可为银星养脑方的批量生产提供参考.
Abstract
Objective To optimize the alcohol extraction of Yinxing Yangnao formula.Methods Based on the single factor experiments,ethanol concentration,extraction time and times of extraction solvent were used as the influence factors.Box-Behnken response surface methodology was used,and the transfer rates of ferulic acid,3,6'-disinapoyl sucrose,sciadopitysin,isoginkgetin and extract yield as evaluation indexes.Combined with G1-entropy weight method,the comprehensive score was calculated to optimize the alcohol extraction of Yinxing Yangnao formula.Results The model predicted that the optimal extraction process was extraction with 6 times of 60％ethanol for 1.4 h and 2 extractions.Conclusion The extraction method is stable and feasible,which can provide a theoretical basis for the mass production of Yinxing Yangnao formula.
关键词
银星养脑方/醇提工艺:G1-熵权法/Box-Behnken响应面法Key words
Yinxing Yangnao formula/alcohol extraction process/G1-entropy weight method/Box-Behnken response surface methodology引用本文复制引用
基金项目
长沙市卫健委中医药科研重点项目(A202304)
湖南省自然科学基金项目(2024JJ9573)
长沙市自然科学基金项目(kq2202497)
湖南省临床医疗技术创新引导项目(2021SK51501)
出版年
2024
NETL
NSTL
万方数据