Research progress in the role of regulated cell death in myocardial ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury(MIRI)is a major cause of negative consequences for patients with myocardial infarction who undergo reperfusion therapy.Regulated cell death(RCD)is a form of orderly and active cell death that plays a crucial role in sustaining normal life processes.Increasing evidence suggests that RCD is actively involved in the development of MIRI and possible key to rescuing damaged myocardial tissue.This article focused on the roles of various forms of RCD,including apoptosis,autophagy,pyroptosis,necroptosis,and ferroptosis,in the progression of MIRI.By deepening our understanding of the pathophysiological process of MIRI,this article aims to provide reference for future clinical treatments of MIRI and drug development.
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