Research advance in oncolytic viruses as anticancer agents for hepatocellular carcinoma
Liver cancer is the sixth most commonly diagnosed cancer worldwide and the third most common cause of cancer death,and is expected to affect more than 1 million people annually by 2025.The existing guideline recommended treatment plan,still can not provide complete cure for liver cancer,and clinical doctors still face high recurrence rate,high mortality,high metastasis rate and other problems.Oncolytic viruses are naturally existing or modified viruses.Oncolytic viruses can selectively replicate and induce cytopathic effects.These characteristics make them very suitable for cancer.This paper summarized the types,mechanism and existing problems of oncolytic viruses,aiming to provide reference for the treatment of liver cancer,developing new therapies and helping more patients.
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