Determination of cinnabar in Xiangsu Zhengwei pills by ICP-MS
Objective To determine the toxic component cinnabar in Xiangsu Zhengwei pills.Methods The sample of Xiangsu Zhengwei pills was dissolved in 5 mL hydrochloric acid-nitric acid(3∶1)before ultrasound.The mixture was diluted with water and 2％nitric acid,and a gold reserve solution was added to achieve a mercury to gold ratio of 1∶200,and then diluted with 2％nitric acid to quantitatively analyze the content of mercury in cinnabar by ICP-MS.Results The mercury concentration was in a good linearity with signal intensity within 0～15 ng·mL-1.The regression equation was Y=2614X+317,r=0.9999,and the average recovery was 97.6％,with RSD of 1.7％.The content of mercury in cinnabar in 3 batches of samples(calculated as mercury sulfide)ranged 5.76～5.85 mg per pill.Conclusion The method is reliable,accurate,and specific,and can effectively control the content of toxic ingredients in the preparation.
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