ICP-MS法测定香苏正胃丸中朱砂的含量
Determination of cinnabar in Xiangsu Zhengwei pills by ICP-MS
高立金 1李杰 1张琳 1卢彩会 1仇晓晴1
作者信息
- 1. 廊坊市药品检验所,河北 廊坊 065000
- 折叠
摘要
目的 建立香苏正胃丸中毒性成分朱砂的含量测定方法.方法 香苏正胃丸样品用盐酸-硝酸(3∶1)5mL超声,使朱砂反应生成可溶性汞盐,用水和2％硝酸稀释,加入金储备液,使含汞和金比例为1∶200,用ICP-MS法对朱砂中的汞进行含量测定.结果 汞的质量浓度在0～15ng·mL-1内与信号强度呈良好的线性关系,回归方程Y=2614X+317,相关系数(r)0.9999,平均回收率为97.6％,RSD为1.7％,3批次样品每丸含朱砂(以硫化汞计)在5.76～5.85 mg内.结论 建立的方法简便可靠、准确性高、专属性强,可用于香苏正胃丸质量控制.
Abstract
Objective To determine the toxic component cinnabar in Xiangsu Zhengwei pills.Methods The sample of Xiangsu Zhengwei pills was dissolved in 5 mL hydrochloric acid-nitric acid(3∶1)before ultrasound.The mixture was diluted with water and 2％nitric acid,and a gold reserve solution was added to achieve a mercury to gold ratio of 1∶200,and then diluted with 2％nitric acid to quantitatively analyze the content of mercury in cinnabar by ICP-MS.Results The mercury concentration was in a good linearity with signal intensity within 0～15 ng·mL-1.The regression equation was Y=2614X+317,r=0.9999,and the average recovery was 97.6％,with RSD of 1.7％.The content of mercury in cinnabar in 3 batches of samples(calculated as mercury sulfide)ranged 5.76～5.85 mg per pill.Conclusion The method is reliable,accurate,and specific,and can effectively control the content of toxic ingredients in the preparation.
关键词
ICP-MS法/香苏正胃丸/毒性成分/朱砂Key words
ICP-MS/Xiangsu Zhengwei pill/toxic component/cinnabar引用本文复制引用
基金项目
河北省药品监督管理局科技计划项目(2023ZC1002)
出版年
2024
NETL
NSTL
万方数据