Retrospective study on the effect of anxiety or depression on the quality of warfarin anticoagulation after heart valve surgery
Objective To determine the influence of anxiety or depression on the quality of warfarin anticoagulation,and timely intervene to improve the quality of warfarin anticoagulation.Methods From January 2020 to May 2023,the patients who were hospitalized for heart valve replacement and regularly took warfarin orally were divided into a study group and a control group according to whether they were accompanied with anxiety or depression.The effect of anxiety or depression on the quality of warfarin anticoagulation was measured.Results Totally 236 patients were included(35 patients in the study group and 201 patients in the control group).The propensity score matching showed that the number of dose adjustments(3.29±1.71),and the maintenance dose of warfarin(3.17±0.84)mg for patients with anxiety or depression were higher than those in the control group(P＜0.05).The proportion of patients with anxiety or depression who achieved high anticoagulation quality(5.71％)and the percentage of time within the therapeutic range(26.00±21.00)％were significantly lower than those of the control group(P＜0.05).Conclusion The quality of warfarin anticoagulation in patients with anxiety or depression is generally low,and such patients need to receive higher doses of warfarin to stabilize the international normalized ratio.
heart valve replacementdepression and anxiety statewarfarinanticoagulant qualitytime within therapeutic range
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