Pharmacoeconomic evaluation of postoperative analgesia in patients undergoing radical gastrectomy with dezocine or pentazocine
Objective To evaluate the pharmacoeconomics of two postoperative analgesia schemes commonly used in radical surgery for gastric cancer.Methods Totally 162 patients with gastric cancer undergoing radical surgery were retrospectively analyzed in a hospital from October 2020 to September 2022.According to the analgesic drugs used,patients were divided into group A and group B.Group A were injected dezocine(76 patients),and group B were injected pentazocine(86 patients).The analgesic effects,adverse reactions and costs of the two groups were analyzed by the cost-effectiveness analysis.Results In terms of safety,the incidence of adverse reactions of group A was 2.63％,and that of group B was 4.65％,with no significant difference(P＞0.05).As to curative effect,the numerical rating scale of group A was lower than that of group B at each time period(P＜0.05).The cumulative effective rates in group A and group B were 96.09％and 70.55％,respectively(P＜0.05).In terms of pharmacoeconomics,the total cost of group A was(969.82±250.76)yuan,and that of group B was(795.62±108.23)yuan.The cost-effectiveness ratio(C/E)was 1010.23 for group A,and 1120.59 for group B,and the incremental cost-effectiveness ratio was 696.80 yuan.The sensitivity analysis supported the cost-effectiveness analysis.Conclusion Dezocine injection has economic advantages over pentazocine injection in postoperative analgesia for gastric cancer.
dezocinepentazocinepostoperative analgesia for gastric canceranalgesic effectpharmacoeconomicscost-effectiveness analysis
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