钩藤碱治疗阿尔茨海默病的药理作用研究进展
Research progress in the pharmacology of rhynchophylline for Alzheimer's disease
张阳 1朱梦宇 1陈垒 1邝莹1
作者信息
- 1. 赣南医科大学,江西 赣州 341000
- 折叠
摘要
阿尔茨海默病(AD)是一种常发于老年人的神经退行性疾病,发病机制复杂,且治疗药物有限,给社会造成了巨大负担.钩藤碱是从中药钩藤中分离得到的一种吲哚类生物碱,具有显著的神经药理作用,可通过多种机制发挥抗AD治疗作用.本文首先对AD可能的发病机制进行总结,深化对AD发病机制的认识,为AD药物开发提供潜在的治疗靶点;同时,也对钩藤碱的神经药理作用进行综述,为以钩藤碱为先导化合物的抗AD药物开发提供新思路.
Abstract
Alzheimer's disease(AD)is a neurodegenerative disease that often occurs in the elderly.Its pathogenesis is complex and treatment drugs are limited,which causes a huge burden to the society.Rhynchophylline is an indole alkaloid isolated from Uncaria rhynchophylla,which has remarkable neuropharmacological and anti-AD therapeutic effects via various mechanisms.This paper summarized the pathogenesis of AD in recent years,and proposed potential therapeutic targets for AD drug development.At the same time,the neuropharmacological action of rhynchophylline was reviewed to provide new ideas for the development of anti-AD drugs with rhynchophylline as the leading compound.
关键词
阿尔茨海默病/病理机制/钩藤碱/药理作用Key words
Alzheimer's disease/pathogenesis/rhynchophylline/pharmacological effect引用本文复制引用
基金项目
国家自然科学基金地区项目(No.82260803)
出版年
2024
NETL
NSTL
万方数据