Optimization of vortex-assisted extraction of strictosamide from Nauclea officinalis by response surface method
Objective To optimize the vortex-assisted extraction of strictosamide from Nauclea offiicinalis with the response surface method.Methods The extraction parameters such as ethanol concentration,vortex rotation,and liquid-solid ratio were optimized through Box-Behnken design based on single-factor experiments.The mathematical model between the parameters and the response values was established to determine the best vortex extraction.Results The optimal conditions included ethanol concentration at 55％,vortex rotation at 1500 r·min-1,liquid-solid ratio of 60 mL/g,and vortex time for 1 min.Under these conditions,the yield of strictosamide was 3.85 mg·g-1,close to the theoretical value of 3.82 mg·g-1.Conclusion The extraction is simple,fast and efficient,which is suitable for extracting alkaloids from Nauclea officinalis.It provides a theoretical basis for the industrial process of Nauclea officinalis.
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